Isolation and Antitumoral Effect of a New Siphonochilone Derivative from African Ginger.

A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan-5-yl acetate (1), has been isolated from the rhizomes of the South African variety of wild ginger (Siphonochilus aethiopicus (Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclear magnetic resonance spectroscopy (NMR) and mass-spectrometric (MS) analyses, including 1D-, 2D-NMR, and HR-LCMS. We also investigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous system cancer lines. The data are not encouraging since its antitumor effect is poor. Nonetheless, the discovery of new molecules may provide a source of new compounds with important biological effects applicable to the field of medicine.

Gender, psychological distress, and subjective well-being two years after the onset of the COVID-19 pandemic in Spain.

This study aimed to examine gender differences in distress and well-being two years after the onset of the COVID-19 pandemic, analyzing risk and protective factors for psychological distress and subjective well-being. It is a repeated cross-sectional study with a sample of 1,588 women (50%) and men (50%) from the general Spanish population aged 18-74 years who were assessed online by seven questionnaires and scales. Descriptive, variance, and hierarchical multiple regression analyses were performed. From February to April 2022, 57.4% of women and 38.7% of men had psychological distress, percentages that totaled 50.5% and 41.5%, respectively, from October 2022 to February 2023. Women also had greater perceived vulnerability to diseases, more negative feelings, and lower affect balance, resilience, and self-esteem than men. The most important predictors of greater psychological distress refer to lower self-esteem, resilience, and social support and higher perceived vulnerability to diseases. Other statistically significant predictors included lower educational level in women and neither being married nor living with a partner in men. Lower self-esteem also best predicted lower subjective well-being, with lower social support and lower resilience also constituting significant predictors. Moreover, lower educational level and higher perceived vulnerability to diseases statistically and significantly predicted lower subjective well-being in women, as did not being a student in men. We conclude that psychological distress remains greatly prevalent in Spain two years after the beginning of the COVID-19 pandemic, especially in women.

Gender, psychological distress, and subjective well-being two years after the onset of the COVID-19 pandemic in Spain / Género, trastorno psicológico y bienestar subjetivo a dos años del inicio de la pandemia de COVID-19 en España / Gênero, distúrbio psicológico e bem-estar subjetivo dois anos após o início da pandemia da COVID-19 na Espanha

Abstract This study aimed to examine gender differences in distress and well-being two years after the onset of the COVID-19 pandemic, analyzing risk and protective factors for psychological distress and subjective well-being. It is a repeated cross-sectional study with a sample of 1,588 women (50%) and men (50%) from the general Spanish population aged 18-74 years who were assessed online by seven questionnaires and scales. Descriptive, variance, and hierarchical multiple regression analyses were performed. From February to April 2022, 57.4% of women and 38.7% of men had psychological distress, percentages that totaled 50.5% and 41.5%, respectively, from October 2022 to February 2023. Women also had greater perceived vulnerability to diseases, more negative feelings, and lower affect balance, resilience, and self-esteem than men. The most important predictors of greater psychological distress refer to lower self-esteem, resilience, and social support and higher perceived vulnerability to diseases. Other statistically significant predictors included lower educational level in women and neither being married nor living with a partner in men. Lower self-esteem also best predicted lower subjective well-being, with lower social support and lower resilience also constituting significant predictors. Moreover, lower educational level and higher perceived vulnerability to diseases statistically and significantly predicted lower subjective well-being in women, as did not being a student in men. We conclude that psychological distress remains greatly prevalent in Spain two years after the beginning of the COVID-19 pandemic, especially in women.

Resumen Este estudio tuvo como objetivo analizar las diferencias de género en distrés psicológico y en el bienestar a dos años del inicio de la pandemia de COVID-19, analizando factores de riesgo y de protección para distrés psicológico y bienestar subjetivo. Se trata de un estudio transversal repetido con una muestra de 1.588 individuos de la población general de España, 50% mujeres y 50% hombres, con edades comprendidas entre 18 y 74 años. Los participantes fueron evaluados en línea mediante 7 cuestionarios y escalas. Se realizaron análisis descriptivos, de varianza y de regresión múltiple jerárquica. Entre febrero y abril del 2022, el 57,4% de las mujeres y el 38,7% de los hombres presentaron distrés psicológico, con porcentajes del 50,5% y 41,5%, respectivamente, entre octubre del 2022 y febrero del 2023. Las mujeres también presentaron una mayor vulnerabilidad percibida a la enfermedad, más sentimientos negativos, menos equilibrio afectivo y menor resiliencia y autoestima que los hombres. Los indicadores más importantes de un mayor distrés psicológico fueron la baja autoestima, la baja resiliencia, el escaso apoyo social y una mayor vulnerabilidad percibida a la enfermedad. Otros indicadores estadísticamente significativos fueron los siguientes: bajo nivel de educación entre las mujeres y no estar casado o no vivir con una compañera entre los hombres. La baja autoestima también fue el mejor indicador de un bajo bienestar subjetivo; además, el escaso apoyo social y la baja resiliencia también fueron indicadores importantes. Además, el bajo nivel de educación y la alta vulnerabilidad percibida a la enfermedad fueron indicadores estadísticamente significativos de bajo bienestar subjetivo entre las mujeres y de no ser estudiantes entre los hombres. Concluimos que el distrés psicológico sigue siendo muy prevalente en España dos años después del inicio de la pandemia de COVID-19, especialmente entre las mujeres.

Resumo Este estudo teve como objetivo analisar as diferenças de gênero em estresse psicológico e no bem-estar dois anos após o início da pandemia da COVID-19, analisando fatores de risco e de proteção para estresse psicológico e bem-estar subjetivo. Este foi um estudo transversal repetido com amostra de 1.588 indivíduos da população geral da Espanha - 50% do sexo feminino e 50% do sexo masculino, com idade entre 18 e 74 anos. Os participantes foram avaliados online por meio de sete questionários e escalas. Foram realizadas análises descritivas, de variância e de regressão múltipla hierárquica. Entre fevereiro e abril de 2022, 57,4% das mulheres e 38,7% dos homens apresentaram estresse psicológico, com porcentagens de 50,5% e 41,5%, respetivamente, entre outubro de 2022 e fevereiro de 2023. As mulheres também apresentaram maior vulnerabilidade percebida à doença, mais sentimentos negativos, menor equilíbrio afetivo e menor resiliência e autoestima do que os homens. Os indicadores mais importantes de maior estresse psicológico foram baixa autoestima, baixa resiliência, baixo apoio social e maior vulnerabilidade percebida à doença. Outros indicadores estatisticamente significativos foram: baixo nível de escolaridade entre as mulheres e não ser casado ou não viver com uma companheira entre os homens. Baixa autoestima também foi o melhor indicador de baixo bem-estar subjetivo; além disso, baixo apoio social e baixa resiliência também foram indicadores significativos. Além disso, baixo nível de escolaridade e alta vulnerabilidade percebida à doença foram indicadores estatisticamente significativos de baixo bem-estar subjetivo entre as mulheres e de não ser estudante entre os homens. Concluímos que estresse psicológico ainda é muito prevalente na Espanha dois anos após o início da pandemia da COVID-19, principalmente entre as mulheres.

Psychological Distress in Alzheimer's Disease Family Caregivers: Gender Differences and the Moderated Mediation of Resilience.

Different studies have reported gender differences in the variables of psychological distress, burden, social support, and resilience in family caregivers of relatives with Alzheimer's disease; however, there is no clear evidence of the specific role of burden, social support, and resilience between gender and psychological distress. The aim of the present study is to clarify the role of these variables. Burden, psychological distress, social support, and resilience have been assessed in a cross-sectional design with a convenience sample of 140 family caregivers of relatives with Alzheimer's disease. Our results confirm gender differences in terms of psychological distress, with higher scores found in female than in male caregivers, whilst male caregivers showed higher scores in terms of resilience than female caregivers. No gender differences have been found in terms of burden and social support. In addition, moderated mediation was obtained via the interaction of gender and social support on resilience, which plays a mediating role in psychological distress. Social support and resilience have shown a protective role concerning the mental health of caregivers, but female caregivers need higher social support to present a similar level of resilience to male caregivers.

The Evolution of Psychological Distress Levels in University Students in Spain during Different Stages of the COVID-19 Pandemic: Risk and Protective Factors.

The present study assesses the evolution of stressful events and psychological distress in male and female students over three different time periods of the COVID-19 pandemic in Spain: the initial "lockdown", with no face-to-face teaching; the "new normality" period, when classes were resumed; and two years after the first wave of the pandemic. The participants were 1200 Spanish university students who were assessed for psychological distress, COVID-19-associated stressful events, social support, and self-esteem. Female students reported more stressful events and higher levels of psychological distress than male students during the "lockdown" and "new normality" time periods of the first wave of the pandemic. However, these differences disappeared in the third period tested, two years after the first wave of the pandemic, with female and male students showing no differences in psychological distress or in the number of stressful events. The main risk predictors of psychological distress during the first wave of the pandemic were lower self-esteem and having suffered a high number of stressful events. The last variable, number of stressful events associated with COVID-19, lost most its effect two years later, when only self-esteem presented a strong and highly significant predictive role.

Diastereoselective C-alkylation of aldimines, derived from chiral α-carbon heteroatom-substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines.

The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and diastereoisomeric ratios. Stereocontrol is induced by the presence of a heteroatom in the α-position to the aldehyde. In the case of alkylation of imines derived from chiral aliphatic amines, good yields and moderate to high diastereoselectivity are obtained: yields are significantly better when the preformed imine is used in the reaction with triethyl borane, and diastereoselectivity of the reactions largely depends on the structure of the chiral aliphatic amine. The methodology is successfully applied to the synthesis of romneine, a natural benzylisoquinoline.

SPION nanoparticles for delivery of dopaminergic isoquinoline and benzazepine derivatives.

Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with a SiO2 shell (SPION@SiO2) and functionalized with carboxyl groups (SPION@SiO2-COOH). A series of new N-alkylamino- and N-alkylamido-terminated 1-phenyl- tetrahydroisoquinolines (THIQs) and 3-tetrahydrobenzazepines (THBs) derivatives presenting -SMe and -Cl groups, respectively, with potential dopaminergic activity, are synthesized and incorporated to the hybrid system. We include the synthetic details for THIQs and THBs derivatives preparation and investigate the influence of the terminal-functional group as well as the number of carbon atoms linked to THIQ and THB molecules during the coupling to the SPION@SiO2-COOH. Nuclear magnetic resonance (NMR) and electron ionization mass spectrometry (EI-MS) are used to characterize the synthesized THIQs and THBs. High-angle annular dark-field transmission electron microscopy (HAADF-TEM), energy dispersive X-ray transmission electron microscopy (EDX-TEM), and proton high-resolution magic angle spinning NMR spectroscopy1H HRMAS-NMR) are used to confirm the presence of THB and THIQ molecules onto the surface of the nanoparticles. The hybrid SPION@SiO2-THIQ and THB systems show significant activity toward the D2 receptor, reaching Ki values of about 20 nM, thus having potential application in the treatment of central nervous system (CNS) diseases.

Gender differences in mental distress and affect balance during the first wave of COVID-19 pandemic in Spain.

The COVID-19 pandemic is a major threat to the health and well-being of people around the world that has impacted freedom of movement, social interaction and the economy. The aim of the present work was twofold: first, to study the presence of mental distress, positive and negative experiences and affect balance in women and men in Spain in two different phases of the COVID-19 pandemic, the initial "first state of alarm" phase, characterized by maximum restrictions, and in the "new normal" phase with minimal restrictions, and second, to study the protective role of age, educational level, self-esteem, marital status and social support against mental distress, and as factors that increase the affect balance of women and men in the above mentioned phases of the first wave of the COVID- 19 pandemic in Spain. The study sample consisted of 652 women and 652 men from the general population, aged between 18 and 88 years, who were evaluated through self-reports. Results show greater mental distress in women than men but, strikingly, the magnitude of such differences were greater in the "new normal" phase than in the maximum restriction phase. In addition, in this last phase, women also experienced more negative feelings and less affect balance than men. High self-esteem and social support were also found to be protective factors for mental health, both in women and men, during the two phases of the pandemic studied. In conclusion, our study shows that the COVID-19 pandemic has especially impacted the well-being of women.

Nanoscale Biocompatible Structures Generated from Fluorinated Tripodal Phenylenes on Gold Nanoprisms.

Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio-devices. We present the fabrication of hybrid systems consisting of triangular prism gold nanoparticles (Au@NTPs) covalently covered with tripod-shaped oligo(p-phenylenes) featuring trifluoromethyl groups. Their synthesis is accomplished using a biphenyl boronic ester as the key compound. Au@NTPs were prepared through a seedless procedure using 3-butenoic acid and benzyldimethyl ammonium chloride, and modified with aminothiol groups. Coverage of this amine-modified gold substrate with a self-assembled monolayer (SAM) of tripod-shaped molecules is carried out in ethanolic solution. The hybrid system avoids up to 70 % of protein corona formation, and allows unspecific attachment for bulky adsorbates, providing an optimal biosensing platform. Chemical composition and morphology are analyzed by transmission electron microscopy (TEM), UV-visible spectroscopy and field emission scanning electron microscopy (FESEM).

Evaluation of the Effects of a Bullying at Work Intervention for Middle Managers.

The aim of the study is to evaluate the effects of a workplace bullying intervention based on the training of middle managers regarding bullying awareness, the consequences of bullying, strategies in conflict resolution and mediation/negotiation abilities. Overall, 142 randomly selected middle managers participated in the study. First, participants completed an information record and two scales assessing bullying strategies, role conflict and role ambiguity. The last two scales were completed again in a second phase three months after the intervention had finished. The intervention produced a decrease in the following bullying strategies: effects on self-expression and communication, effects on personal reputation and effects on occupational situation and quality of life, with all of the mentioned bullying strategies being suffered by part of the sample. In addition, the conflict role decreased in the group which received the intervention. Moreover, the decrease in the effects of the bullying strategy effects on occupational situation and quality of life was especially important in managers with higher responsibilities within the workplace. Results are discussed in the framework that (1) leadership practices and, more specifically, conflict resolution skills are strongly responsible for bullying at work; and (2) the importance of intervening in the early stages of the bullying process as a key element in the correction, but also as a potential prevention element, of bullying in the workplace.

Stress and Psychological Distress in Emerging Adulthood: A Gender Analysis.

Emerging adulthood is a critical period of life that entails many life transitions in living arrangements, relationships, education and employment, which can generate stress and psychological distress in the emerging adult. The aim of the present study was to assess the relevance of stress, coping styles, self-esteem and perceived social support in the distress of emerging adult women and men. The sample consists of 4816 people (50% females) from the Spanish general population, ranging in age from 18 to 29 years old. All participants were assessed through questionnaires and scales that assess psychological distress, stress, coping styles, self-esteem and social support. Women scored higher than men in psychological distress, chronic stress, minor daily hassles, emotional coping style and social support, whereas men scored higher than women in rational and detachment coping styles and in self-esteem. Psychological distress was significantly predicted in women and men by high emotional coping style, lower self-esteem, high number of life events, and less social support. Another statistically significant predictor in men was less detachment coping style, whereas in women it was high chronic stress. The results of this research are relevant to healthcare professionals interested in improving the mental health of the emerging adult.

Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery.

Here, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, magnetic nanoparticles (@Fe3O4) are synthesised by co-precipitation approach and functionalised with acrylic acid (AA), 3-butenoic acid (3BA) or allylamine (AL) as comonomers. The thermo-responsive polymer is grown by free radical polymerisation using N-isopropylacrylamide (NIPAM) as monomer, N,N'-methylenbisacrylamide (BIS) as cross-linker, and 2,2'-azobis(2-methylpropionamidene) (V50) as initiator. We evaluate particle morphology by transmission electron microscopy (TEM) and particle size and surface charge by dynamic light scattering (DLS) and Z-potential (ZP) measurements. These magnetically active pNIPAM@ nanoformulations are loaded with 5-fluorouracil (5FU) and oxaliplatin (OXA) to determine loading efficiency, drug content and release as well as the cytotoxicity against T-84 colon cancer cells. Our results show high biocompatibility of pNIPAM nanoformulations using human blood cells and cultured cells. Interestingly, the pNIPAM@Fe3O4-3BA + 5FU nanoformulation significantly reduces the growth of T-84 cells (57% relative inhibition of proliferation). Indeed, pNIPAM-co-AL@Fe3O4-AA nanosystems produce a slight migration of HCT15 cells in suspension in the presence of an external magnetic field. Therefore, the obtained hybrid nanoparticles can be applied as a promising biocompatible nanoplatform for the delivery of 5FU and OXA in the improvement of colon cancer treatments.

Gender, exercise, and health: A life-course cross-sectional study.

The purpose of this study is to explore relationships between the practice of exercise, gender, and health, from adolescence to old age, testing the magnitude of gender differences throughout the life cycle in the practice of exercise of Spanish people. A cross-sectional study with 4,575 women and 4,334 men, aged 13-85 years, was conducted. The participants were assessed on the weekly hours they dedicated to the practice of exercise, masculine/instrumental and feminine/expressive traits, mental health symptomatology, and self-rated health). Univariate and multivariate analyses were performed in the age groups of adolescence, late adolescence, young adulthood, middle adulthood, and older age. Results showed that men dedicated significantly more hours to the practice of exercise than women within all age groups, except in older age (men´s average = 4.07; women´s average = 2.55). The masculine/instrumental trait played a mediating role between gender and practice of exercise hours. Furthermore, a decline in the amount of time dedicated to exercise from adolescence to older age was found, with higher drops in men. Finally, the practice of exercise was associated with better self-rated health and less mental symptoms. These results underline the important role that gender and masculine-instrumental trait play on the practice of exercise .

The Role of Age and Gender in Perceived Vulnerability to Infectious Diseases.

Background: The study of the immune system has been approached using two separate paths, the biological immune system and the behavioral immune system. Recently, Gangestad and Grebe proposed a unique integrated compensatory immune system, where both systems work together and one of them could compensate for the other when necessary. However, few studies have confirmed the existence of this integrated compensatory immune system. Our study represents an attempt to explore the existence of this unique immune system, investigating if the behavioral immune system variables increase when the biological immune system weakens with age. Material andMethods. The cross-sectional design study was made up of a final sample of 1108 participants (45.2% men and 54.2 women) aged 18-64 years. The younger group (18-21 years) was made up of students, whilst the older groups (22 to 64 years) were composed by their relatives and acquaintances, following the snow ball process. The participants completed the Perceived Vulnerability to Disease Questionnaire that assesses perceived infectability and germ aversion. Correlations, analyses of variance (ANOVAs), and independent group comparisons were performed. These analyses showed the relationships between the variables studied, the effects of age and gender in perceived infectability and germ aversion, and the differences that perceived infectability and germ aversion presented in different age-groups separated by gender. Results: A pattern emerged where germ aversion increases as both men and women get older, but perceived infectability decreases up to the age of 50, and then it increases in women from that age onward. Gender differences are only significant in younger participants, with women having higher scores than men in both variables. Conclusion: The results partially support the existence of a unique integrated compensatory biological/behavioral immune system.

Optimism as a key to improving mental health in family caregivers of people living with Alzheimer's disease.

Objective: The aim of the present work was to study the serial multiple mediating role of optimism, perceived social support and subjective burden in the relationship between objective burden and psychological distress in caregivers of people with Alzheimer´s Disease (AD).Method: One hundred and forty family caregivers of people living with AD were recruited from randomly selected Alzheimer Association Centres. They answered the General Health Questionnaire (GHQ), the Life Orientation Test-Revised (LOT-R), the Functional Social Support Questionnaire (DUKE.UNC), the Zarit Burden Interview (ZBI) and questions relating to gender, age and the amount of time spent on daily caregiving.Results: Results indicated that objective burden and subjective burden were both high in these caregivers. Optimism mediated on psychological distress through social support and through subjective burden with a full mediation role. When comparisons between indirect effects were performed, optimism was the mediator with the greatest effect between objective burden and psychological distress.Conclusion: This study highlights the indirect role of optimism and the advantages that interventions in optimism training in the early stages of the person with AD could produce. Thus, alleviating subjective burden and increasing perceived social support, which would lead to an improvement in the mental health of family caregivers of people with AD.

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy.

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines.

A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affinity and selectivity for D1 and D2 dopaminergic receptors was studied. Moreover, N-alkyl salts of these tetrahydroisoquinolines were used as starting material to synthesize a series of new 1-aryl-7,8-dihydroxy 3-tetrahydrobenzazepines derivatives with electron-withdrawing substituents at C-2 position by the diastereoselective Stevens rearrangement. The structure-activity relationship of these compounds was explored to evaluate the effect of the functional group at C-2 in benzazepines and the modification in the aryl group at the isoquinoline C-1 position towards the affinity and selectivity for the mentioned receptors. The 1-aryl-6,7-dihydroxy tetrahydroisoquinoline 4c shows significant affinity towards D2 receptor, with Ki value of 31 nM. This significant affinity can be attributed to the presence of a thiomethyl group, and it is the most active 1-aryl-6,7-dihydroxy tetrahydroisoquinoline derivative reported to date.

Ex post-facto study of long term stress in a sample of adoptees / Estudio ex post-facto del estrés a largo plazo en una muestra de personas adoptadas

In this work we study the impact of relinquishment and the adoption process in posttraumatic symptoms in a group of 55 adults that were adopted as children before 1970. The effects of institutionalization, maltreatment, traumatic revelation of the adopted status and stressful life events have also been studied. No significant differences were found between institutionalized and non-institutionalized adoptees in posttraumatic symptomatology. However, adoptees who suffered maltreatment, traumatic revelation and high level of stressful life events scored significantly higher in intrusion and arousal than those adoptees non-maltreated, without traumatic revelation and with low level of stressful life events respectively. Traumatic revelation, alone or in association with maltreatment, seems to play an important role in posttraumatic symptoms in the sample studied

En este trabajo estudiamos el impacto que el proceso de abandono y adopción tuvieron en sintomatología postraumática en una muestra de 55 adultos que fueron adoptados con anterioridad a 1970. También se ha estudiado el efecto de la institucionalización, el maltrato, la revelación traumática del estatus de adoptado y los acontecimientos vitales estresantes. No se han encontrado diferencias significativas entre adoptados que fueron institucionalizados y aquellos que no lo fueron en sintomatología postraumática. Sin embargo, los adoptados que sufrieron maltrato, revelación traumática y altos niveles de sucesos vitales estresantes puntuaron más alto de un modo significativo en intrusión y arousal que aquellos adoptados que respectivamente no sufrieron maltrato, ni revelación traumática y que sus niveles de acontecimientos vitales estresantes eran bajos. Revelación traumática, sola o en asociación con maltrato, parece jugar un importante papel en la sintomatología postraumática encontrada en la muestra estudiada

Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands.

Hexahydroindenopyridine (HHIP) is an interesting tricyclic piperidine nucleus that is structurally related to melatonin, a serotonin-derived neurohormone. Melatonin receptor ligands have applications in several cellular, neuroendocrine and neurophysiological disorders, including depression and/or insomnia. We report herein an efficient two-step method to prepare new HHIP via enamine C-alkylation-cyclization. The influence of substituents on the benzene ring and the nitrogen atom on melatoninergic receptors has been studied. Among the 25 synthesized HHIPs, some of them containing methylenedioxy (series 2) and 8-chloro-7-methoxy substituents (series 4) on the benzene ring revealed affinity for the MT1 and/or the MT2 receptors within the nanomolar range or low micromolar. Similar activities were also encountered for those presenting urea (4g), N-aryl (2e) and N-alkyl (2f) acetamide functions. Therefore, new synthesized compounds with a HHIP nucleus have emerged as new promising leads towards the discovery of melatoninergic ligands which could provide new therapeutic agents.